Analytical studies carried out on the vibro-acoustic response behavior of an isotropic plate under non-uniform edge loads subjected to steady-state mechanical excitation is presented. An analytical method based on the energy approach is used to calculate the buckling load (Pcr). Free and forced vibration responses of the plate are obtained using an analytical method based on Reddy's third-order shear deformation theorem (TSDT) while sound radiation behavior is analyzed using Rayleigh Integral. Results revealed that Pcr is significantly influenced by the nature of non-uniform edge load. Similarly, natural frequencies reduce with an increase in axial compressive load due to a reduction in structural stiffness. Vibration and acoustic resonant amplitudes are affected by the intensity of the compressive load. Sound transmission loss reduces with an increase in compressive load magnitude and the effect is significant in the stiffness dominant region. © 2020 Elsevier Masson SAS