Vellore Institute of Technology (VIT) is a private university located in&nbsp;Tamil Nadu, India. Founded in 1984, as Vellore Engineering College, the institution offers 20 undergraduate, 34 postgraduate, four integrated and four research programs. It has campuses in Vellore, Amravati, Bhopal and Chennai.

VIT is one of the top ranked private universities in India according to NIRF, THE and QS Rankings.&nbsp;Govt. of India has recognized&nbsp;VIT, Vellore as an&nbsp;Institution of Eminence. This has allowed VIT to take independent quality initiatives and move up in world ranking.

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VIT University

This study reports the third-order nonlinear optical (NLO) properties of hexamethylenetetramine (HMTA) stabilized pure and transition metals (Cu, Co and Mn) doped ZnS nanoparticles (NPs) and their electronic structures. The third-order NLO properties of pure and transition metals (Cu, Co and Mn) doped ZnS NPs were measured by [Formula: see text]-scan technique. From these measurements, the pure and doped ZnS samples exhibit negative nonlinearity i.e., self-defocusing. The open aperture [Formula: see text]-scan measurement shows saturated absorption within the medium. The prepared pure and doped ZnS samples exhibit nonlinear refractive index of the order of 10[Formula: see text][Formula: see text](cm2/W), nonlinear absorption (NLA) coefficient of the order of 10[Formula: see text][Formula: see text]cm/W and nonlinear optical susceptibility of the order of 10[Formula: see text][Formula: see text]esu. The electronic structures of these ZnS NPs were investigated using near edge X-ray absorption fine structure (NEXAFS) measurements at the C K-, N K- and Co L[Formula: see text]-edges. The C K- and N K-edges XANES spectra reveal the appearance of several spectral features in the range 285–290[Formula: see text]eV and 390–430[Formula: see text]eV respectively. The Co L[Formula: see text]-edge NEXAFS spectrum exhibits multiplet absorption lines similar to those of Co[Formula: see text] ions coordinated in tetrahedral symmetry with four sulfur nearest neighbors. These results clearly demonstrate that divalent Co ions substitute Zn sites. From the Raman spectra, the appearance of multiple resonance Raman peaks indicates that the prepared ZnS samples have good optical quality.

World University root node

Physics

School of Advanced Sciences

Chennai Campus

Department of Communication Engineering

School of Electronics Engineering

Vellore Campus

Mechanical

School of Mechanical Engineering

Department of Thermal and Energy Engineering

Journal of Nonlinear Optical Physics & Materials

Enhancement of third-order nonlinear optical properties of HMTA stabilized pure and doped ZnS nanoparticles and their electronic structures

Toxins are one among the numerous virulence factors produced by the bacteria. These are powerful poisonous substances enabling the bacteria to encounter the defense mechanism of human body. The pathogenic system of Staphylococcus aureus is evolved with various exotoxins that cause detrimental effects on human immune system. Four toxins namely enterotoxin A, exfoliative toxin A, TSST-1 and γ-hemolysin were downloaded from Uniprot database and were analyzed to understand the nature of the toxins and for drug target validation. The results inferred that the toxins were found to interact with many protein partners and no homologous sequences for human proteome were found, and based on similarity search in Drugbank, the targets were identified as novel drug targets.

Department of Integrative Biology

School of Bio Sciences and Technology

Infectious Disorders - Drug Targets

In silico Analysis of Toxins of Staphylococcus aureus for Validating Putative Drug Targets

Department of Physics

Fulltext

The Astrophysical Journal

A HOT COMPANION TO A BLUE STRAGGLER IN NGC 188 AS REVEALED BY THE ULTRA-VIOLET IMAGING TELESCOPE (UVIT) ON ASTROSAT

This paper reports on the preparation of high purity ZnS nanoparticles by a facile single step solvent-free route via thermal decomposition of zinc acetate dihydrate and thiourea in air atmosphere. The third-order optical nonlinearity of the prepared ZnS nanoparticles were measured by Z-scan technique using continuous wave 532-nm diode pumped Nd:YAG laser. From nonlinear optical (NLO) measurements, the prepared ZnS nanoparticles possess negative nonlinearity i.e., self-defocusing. Open aperture Z-scan measurement shows saturable absorption within the medium. These results show that the prepared ZnS nanoparticles are promising candidate for various potential applications in the field of nonlinear optics.

Enhanced third-order nonlinear optical properties of high purity ZnS nanoparticles

High pressure die casting is the best suitable method for the manufacturing of Heavy Vehicle Engine Components. The design of feed system was done by Pro E wildfire 4.0 and the movement of molten metal inside the cavity was analyzed using the Magma software for an injection pressure of 600 kgf/cm2.The die for the Heavy Vehicle Engine Components was designed and manufactured. The engine components were manufactured with the help of 250 T locking force capacity high pressure die casting machine. The radiographic inspections for some of the sample components were carried. The hardness of the Heavy Vehicle Engine Components and the porosity levels were evaluated. The component’s dimensions were checked by a co-ordinate measuring machine.

Department of Manufacturing Engineering

Advanced Materials Research

Design and Development of a High Pressure Die Casting Technique for Manufacturing Heavy Vehicle Engine Components

The aim of the study was to predict and analyze the molecular interactions between the drug target named γ-hemolysin of <a href="http://www.scialert.net/asci/result.php?searchin=Keywords&amp;cat=&amp;ascicat=ALL&amp;Submit=Search&amp;keyword=Staphylococcus+aureus">Staphylococcus aureus</a> and various flavonoid compounds. Binding affinity for the complexes were calculated based on the free binding energies and the number of interactions. The receptor is a bicomponent, β-barrel pore forming toxin associated with several clinical diseases. The cytolytic and hemolytic activity of the toxin and its involvement in the pathogenesis by damaging the host membranes proved γ-hemolysin to be a valid drug target. The 3D structure of γ-hemolysin downloaded from PDB database (PDB ID: 2QK7) was docked with flavonoid compounds having antimicrobial property. The SMILES of the twenty compounds were obtained from NCBI Pubchem Compound database and downloaded PDB files from Corina tool. Drug-like property and drug-likeness of the compounds were checked by Lipinski’s Rule. Molecular docking was done using Autodock 4.0 resulting in binding energies and the docked complexes were analyzed by PyMol which revealed the binding pattern of <a href="http://www.scialert.net/asci/result.php?searchin=Keywords&amp;cat=&amp;ascicat=ALL&amp;Submit=Search&amp;keyword=amino+acid">amino acid</a>s of the receptor with the ligands. Docking analysis revealed that the residue SER90 play an important role in binding with the ligands. The binding energy values of the docked complexes ranged between -6.49 to -5.02 kcal moL-1. A more negative binding energy was found with Ponciretin compound with -6.49 kcal moL-1. The lower energy indicated that the compound was in stable conformation and had higher affinity towards the receptor. Thus, Ponciretin compound would be a possible drug compound for inhibiting the cytotoxic and hemolytic activity of the toxin.

Trends in Bioinformatics

In silico Molecular Interaction Studies of Gamma-hemolysin of Staphylococcus aureus with Flavonoid Compounds

VIT Unitversity

Bioinformation

Computational structural and functional analysis of hypothetical proteins of Staphylococcus aureus