Vellore Institute of Technology (VIT) is a private university located in&nbsp;Tamil Nadu, India. Founded in 1984, as Vellore Engineering College, the institution offers 20 undergraduate, 34 postgraduate, four integrated and four research programs. It has campuses in Vellore, Amravati, Bhopal and Chennai.

VIT is one of the top ranked private universities in India according to NIRF, THE and QS Rankings.&nbsp;Govt. of India has recognized&nbsp;VIT, Vellore as an&nbsp;Institution of Eminence. This has allowed VIT to take independent quality initiatives and move up in world ranking.

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VIT University

Chemistry

The synthesis of 4-aryl-2H-pyran-2-ones 7 was accomplished by rearrangement of 6-aryl-2H-pyran-ones 5 with ethyl cyanoacetate 6 in the presence of a base in DMF at room temperature. The reaction products were achieved in good yields. The reaction products were characterized by their spectroscopic analysis. The structure of compound 7a was confirmed by its single crystal X-ray analysis. Moreover, single crystal X-ray study of compound 7a showed rare plausible peri oxygen-oxygen interactions between O2 and O3. Further compound 7a showed homodimer intermolecular H-bonding interactions between nitrogen and OH groups along with a-b plane. These non-covalent interactions stabilized compound 7a in the crystalline state. © 2021 Elsevier B.V.

World University root node

School of Advanced Sciences

Chennai Campus

Journal of Molecular Structure

Metal-free synthesis and single crystal X-ray analysis of 4-aryl-6-hydroxy-2Η-pyran-2-cyanomethylenes

Synthesis of phase pure Sb2S3 in open atmosphere has been a long-time challenging task due to the oxidation of metal. Here, we demonstrate a robust, one-step solution approach for synthesis of Sb2S3 thin films in open air atmosphere. One-step thermolysis of Sb-MPA complex obtained by mixing antimony chloride and 3-Mercaptopropionic acid (3-MPA) in polar and non-polar solvents yields phase pure thin films. Upon changing the concentration of sulphur in the solvent and polarity of solvent, different microstructures of Sb2S3 such as nanostripes, nanorods and tubular morphology evolve. Irrespective of sulphur concentration in the precursor solution, Sb2S3 thin films are always phase pure and formed in stoichiometric composition. The films are photoconductive in nature and morphology of Sb2S3 influences the photoconductivity. This novel and facile methodology will open new avenues for direct deposition of Sb2S3 thin films for wide range of applications including optoelectronics, photovoltaics and photocatalysis research. © 2020 Elsevier Ltd

Materials Science in Semiconductor Processing

One step thermolysis of Sb-Mercaptopropionic acid complex in ambient air atmosphere for growing Sb2S3 thin films with controlled microstructure

Neglected tropical diseases (NTDs) as termed by WHO include twenty different infectious diseases that are caused by bacteria, viruses, and parasites. Among these NTDs, Chagas disease and leishmaniasis are reported to cause high mortality in humans and are further associated with the limitations of existing drugs like severe toxicity and drug resistance. The above hitches have rendered researchers to focus on developing alternatives and novel therapeutics for the treatment of these diseases. In the past decade, several target-based drugs have emerged, which focus on specific biochemical pathways of the causative parasites. For leishmaniasis, the targets such as nucleoside analogs, inhibitors targeting nucleoside phosphate kinases of the parasite’s purine salvage pathway, 20S proteasome of Leishmania, mitochondria, and the associated proteins are reviewed along with the chemical structures of potential drug candidates. Similarly, in case of therapeutics for Chagas disease, several target-based drug candidates targeting sterol biosynthetic pathway (C14-ademethylase), L-cysteine protease, heme peroxidation, mitochondria, farnesyl pyrophosphate, etc., which are vital and unique to the causative parasite are discussed. Moreover, the use of nano-based formulations towards the therapeutics of the above diseases is also discussed. © Copyright © 2021 J, M and Chanda.

Department of Chemistry

Vellore Campus

Fulltext

Frontiers in Chemistry

An Overview on the Therapeutics of Neglected Infectious Diseases—Leishmaniasis and Chagas Diseases

The Nano Hydroxyapatite (HAp), HAp/PEG and HAp/PVP powders derived from both Gastropod shell (natural source) and chemical precursor by the precipitation method were characterized through various characterization techniques such as FT-IR, XRD, SEM-EDX, TEM, Antibacterial activity and SBF analysis. Based on the structural, chemical, morphological and biological characteristics, HAp/PVP from natural and chemical precursors have been compared. Calculated structural parameters, crystallinity index, C/P ratio, morphology, antibacterial activity and SBF analysis of the products show that HAp/PVP-S (derived from a natural source) exhibits good mechanical property, rod like morphology, good antibacterial activity and apatite formation ability after 14 days. EDX analysis also shows the presence of carbon and sodium in HAp/PVP-S. Comparative analysis reveals that characteristics of HAp/PVP-S such as high carbonate content, low crystallite size, poor crystalline nature, presence of trace metal, non-stoichiometric elemental composition and rod like crystals which are matched with the characteristics of biological apatite. Thus, the HAp/PVP-S has the ability to form bone apatite. © 2021, Iran University of Science and Technology. All rights reserved.

Iranian Journal of Materials Science and Engineering

Structural, morphological and anti-bacterial analysis of nanohydroxyapatite derived from biogenic (Shell) and chemical source: formation of apatite

Chemistry of hypervalent iodine reagents have developed extensively after the discovery of IBX as a commercial reagent in organic synthesis. Their stability in air, environmentally nature and unique reactivity under mild reaction conditions makes them more suitable reagents for medicinal and natural product chemistry. Various synthetic transformations have been achieved by using hypervalent iodine reagents under mild reaction conditions. Hypervalent iodine catalysis is identified as an emerging research area in past couple of decades. In past few years, hypervalent iodine reagents have found their application in photoredox catalysis. In this review article, the progress of photoredox catalysis by involving hypervalent iodine reagents would be covered. © 2021 Arkat. All rights reserved.

Arkivoc

Hypervalent iodine chemistry and light: Photochemical reactions involving hypervalent iodine chemistry

Hypervalent iodine chemistry has witnessed exponential growth in organic synthesis in recent times. Because of the electrophilic and good-leaving nature of hypervalent iodine reagents, they react with different nucleophiles in various synthetic transformations such as rearrangements, α-functionalization of carbonyl compounds, alkene difunctionalization and oxidation reactions. Importantly, the application of hypervalent iodine reagents in the construction of heterocycles is of great interest and has been well studied over the years. This review article highlights the recent developments accomplished by hypervalent iodine reagents in the synthesis and functionalization of heterocyclic compounds. © 2021 Arkat. All rights reserved.

Hypervalent iodine-mediated synthesis and late-stage functionalization of heterocycles

Cuprous oxide (Cu2O) nanoparticles (Nps) were synthesized using the vegetable waste viz. Daucus carota (Carrot) peel and agro wastes Cocos nucifera (Coconut) husk and Artocarpus heterophyllus (Jackfruit) seed. X-ray diffraction analysis confirmed the formation of cubic Cu2O nanoparticles having high crystallinity. Microscopy analysis of the synthesized Cu2O nanoparticles using D. carota and A. heterophyllus revealed spheroidal-like cluster formation, whereas rice spikelet nanostructures were observed in the case of C. nucifera synthesized Cu2O Nps. Energy-dispersive X-ray spectra of all the nanoparticles showed the presence of Cu and Oin the desired ratio, confirming the stoichiometry. Fourier transform infrared spectra revealed the presence of the functional groups responsible for the synthesis of the nanoparticles. The antimicrobial activity studies of the synthesized Cu2O nanostructures showed satisfactory results against the bacterial and fungal species. Hence the vegetable and agro-waste may be regarded as a biofactory for synthesizing the Cu2O nanoparticles. © 2021 Wiley-VCH GmbH

ChemistrySelect

Phytochemical-Assisted Synthesis of Cuprous Oxide Nanoparticles and Their Antimicrobial Studies

A metal-free, ultrasound-assisted, fast synthesis of fluorescent N-Boc-protected 1,2,3,4–tetrahydroquinolines 9a-p is described through carbanion-induced ring transformation of 6-aryl-2H-pyran-2-ones 7 with tert‑butyl 3-oxopiperidine-1-carboxylate 8 under basic condition. The reaction products 9a-p were isolated in high yields. Our synthetic approach is flexible for introducing electron-withdrawing and electron-donating groups. All the synthesized 1,2,3,4–tetrahydroquinolines 9a-p showed blue fluorescence in the range of 422–470 nm. Based on the optical behavior of compounds 9a–p, we calculated stokes shift, quantum yield and optical band gap which are highly influenced by the substituents in the ring. © 2020 Elsevier B.V.

Physics

Synthesis, spectral characterization and photophysical studies of tetrahydroquinolines

We report a facile and low-cost solution-based approach to synthesize various binary, ternary and quaternary metal chalcogenide thin films. Homogeneous metal chalcogenides single precursor is prepared by dissolving metal salt (metal chloride/acetate) in ethanolic/methanolic solution of 3-Mercaptopropionic acid (MPA) at room temperature. High-quality CdS, ZnS, Sb2S3, CuInS2 (CIS) and Cu2ZnSnS4 (CZTS) metal sulfide thin films are successfully synthesized by thermalizing these metal-MPA precursor solution at 350 °C in air for 15 min. The mechanism of metal sulfide formation is analyzed by FTIR and thermogravimetry coupled with mass spectrometry. This study highlights the formation of intermediate metal-MPA complex as a single precursor, which eventually decomposes into metal sulfide upon heating at 350 °C. The film thickness, morphology and composition of metal sulfide can be controlled by the concentration of reactants, deposition cycles and the choice of solvent. XRD, Raman, UV–vis spectroscopy, diffuse reflectance spectroscopy and energy dispersive analyses ascertain the phase purity of the films. Bandgap estimates, morphology, narrow Urbach width with low defect densities in the bandgap region, uniform thickness discerned from cross-section SEM, uniformity in the elemental maps and the photoconductivity studies further confirm high-quality of the films. Attaining molecular-level homogeneous precursor solution and inertness to the air ambient enables precise control on the stoichiometry and the enhanced uniformity of deposited films. This facile method will have potential application in large scale synthesis of different metal chalcogenide thin films by a thermolysis process and is highly suitable for controlling stoichiometry and spatial uniformity of deposited films sought in solar cell, optoelectronic and catalysis applications. © 2021 Elsevier Ltd

Materials Research Bulletin

Fabrication of metal chalcogenide thin films by a facile thermolysis process under air ambient using metal-3-mercaptopropionic acid complex

In this work, we report the one-pot fabrication of nanoarchitectured hydrotalcite (HT)/SBA-15 composites via a facile in-situ mesoporous templating approach. The characterization studies conferred that the successful incorporation of HT into the SBA-15 mesopores and the formation of composites. These composites showed excellent performance towards the catalytic conversion of biomass-derived levulinic acid (LA) to a biofuel additive ethyl levulinate (EL). The enhancement in the selectivity of EL was observed from 69 to 97% with the incorporation of HT into SBA-15. The experimental results revealed that the catalytic activity of the composites was thoroughly influenced by the density of surface basic sites and surface area. Among all the composites, HTS-2 outperforms the highest EL selectivity of 97.2% with remarkable stability and recyclability. © 2021, Springer Nature B.V.