Vellore Institute of Technology (VIT) is a private university located in&nbsp;Tamil Nadu, India. Founded in 1984, as Vellore Engineering College, the institution offers 20 undergraduate, 34 postgraduate, four integrated and four research programs. It has campuses in Vellore, Amravati, Bhopal and Chennai.

VIT is one of the top ranked private universities in India according to NIRF, THE and QS Rankings.&nbsp;Govt. of India has recognized&nbsp;VIT, Vellore as an&nbsp;Institution of Eminence. This has allowed VIT to take independent quality initiatives and move up in world ranking.

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VIT University

Department of Biotechnology

School of Bio Sciences and Technology

Vellore Campus

natural resources for human health

Phytochemical-loaded Nanoparticles in COVID-19 Management (NRFHH-00320-2023-02) Suneetha Vuppu and Toshika Mishra

Breast cancer is one of the most common malignancies affecting women worldwide, emphasizing the need for effective therapeutic strategies. Phytochemicals derived from plants have gained significant attention due to their potential anticancer properties.<h3>Objective</h3>This review aims to comprehensively assess the existing literature on using phytochemical-loaded formulations as a therapeutic approach for breast cancer. By analyzing the available evidence, we aim to determine the potential benefits and limitations of these formulations in terms of their anticancer activity, bioavailability, and safety.<h3>Methods</h3>A systematic search of relevant databases was conducted to identify studies investigating phytochemical-loaded formulations in the context of breast cancer treatment. The inclusion criteria encompassed clinical trials, preclinical studies, and in-vitro experiments that reported using phytochemicals in various formulations for breast cancer treatment. Data extraction was performed to ensure the reliability and validity of the included studies.<h3>Results</h3>The review highlights the diverse range of phytochemicals used in different formulations for breast cancer treatment. Findings suggest that these formulations exhibit promising anticancer effects by targeting multiple signaling pathways in breast cancer progression, including cell proliferation, apoptosis, angiogenesis, and metastasis. Moreover, various delivery systems, such as nanoparticles, liposomes, and micelles, have enhanced phytochemicals' bioavailability and targeted delivery.

Clinical Complementary Medicine and Pharmacology

Phytochemical Loaded Nanovehicles of Biopolymer for Breast Cancer: A Systemic ReviewSuneetha and Toshika

<h2>&nbsp;</h2><h2>Abstract</h2>Keratin, a versatile bioprotein, has seen a tremendous industrial exploitation due to its outstanding biodegradability and biocompatibility nature. Keratin is primarily derived from substrates such as feathers, nails, horns, beaks, hair and bovine hoofs. The generation of chicken and pigeon feather wastes has risen over the years in Vellore. When it is not discarded properly, this acts as a major root cause for the dissemination of various diseases to humans. The primary aim of this research is to remediate these wastes by extracting the keratin and to prove that beta-mercaptoethanol enhances keratinase activity by in-silico approach for degradation of these wastes. In light of this, the feathers from the dumped sites of Vellore were exploited and the keratin was extracted from country chicken and pigeon feathers which yields a concentration of 3.44&nbsp;mg/L and 2.8&nbsp;mg/L of keratin. This extraction procedure is significantly more cost-effective and yields more keratin than earlier approaches.

Kuwait journal of science

In-silico study of bacterial keratinase and optimization of extraction procedure for keratin from country chicken and Indian blue rock pigeon feathers Sathvika kamaraj  and Suneetha Vuppu

critical reviews in toxiclogy

"Toxicity of Chemical-based Hand Sanitizers on Children and the Development of Natural Alternatives: A Computational Approach"T misra,Vuppu S

Molecular biotechnology

<figure class="table"><table><tbody><tr><td>Title </td></tr><tr><td><a href="https://links.springernature.com/f/a/mn4TQQvSWXPNd4OZuixe8w~~/AABE5gA~/RgRnQKs2P0TNaHR0cHM6Ly90cmVidWNoZXQucHVibGljLnNwcmluZ2VybmF0dXJlLmFwcC9nZXRfY29udGVudC9jYmZmMjJkNi05YmRiLTQzZjgtOWU5OC1kOTI1N2IyZGI0OTE_dXRtX3NvdXJjZT1yY3RfY29uZ3JhdGVtYWlsdCZ1dG1fbWVkaXVtPWVtYWlsJnV0bV9jYW1wYWlnbj1ub25vYV8yMDIzMTEyMiZ1dG1fY29udGVudD0xMC4xMDA3L3MxMjAzMy0wMjMtMDA5NzAtMVcDc3BjQgplVTYmXmVIL1zYUhN2c3VuZWV0aGFAdml0LmFjLmluWAQAAAct">Microalgae-Based Disinfectant Formulation for Aseptic Processing of Ethiopian Ingredient-Sourced Functional Bread and Its Molecular Docking Analysis to Reduce Hypernatremia</a> </td></tr></tbody></table></figure>

Abstract: Food Science and Engineering have become a rapidly evolving domain that has gained prominence in recent years to facilitate the development of enriched food products (like functional foods). It is utilized as a prophylactic measure for several health conditions like osteoporosis, obesity, cardiovascular diseases, and so on. Functional foods perform prophylactic activity through components like phytochemicals in their ingredients which may interact with the target receptors in susceptible people. The post-menopausal women become susceptible to numerous complications, including bone atrophy, osteoporosis, depression, dementia, obesity, vasomotor symptoms, and other lifestyle disorders. As reduced estrogen production is the major reason for such conditions’ development, therapeutic interventions like hormone replacement therapy are administered to treat the complications associated with post-menopause. Hormone therapy is identified to be associated with some important limitations. This gives rise to the need to develop safer approaches for prophylaxis of post-menopausal adverse. In this review, we attempt to propose a design of functional idli made up of oats (Avena sativa), soybean (Glycine max), decorticated black gram (Vigna mungo), rice (Oryza sativa), moringa leaves (Moringa oleifera), spinach (Spinacia oleraceae) and fenugreek (Trigonella foenum-graceum) as a prophylactic measure to reduce post-menopausal adverse effects in women. These ingredients are sources of phytoestrogen (that structurally mimics human estrogen), consumption of which is beneficial in promoting healthy life in post-menopausal women. Computational studies like molecular docking can be utilized for in-silico validation of the efficacy of the formulation by demonstrating the effective binding of the phytoestrogens with the estrogen receptors α and β. Keywords: functional food, idli, molecular docking, phytoestrogens, post-menopause&nbsp;

Proposed Design and In-silico Studies of Functional Idli as a Prophylactic Measure to Reduce Post-Menopausal Adverse Effects in Women S Vuppu and  M.Toshika

In Silico Study of&nbsp;Enzymatic Degradation of&nbsp;Bioplastic by&nbsp;Microalgae: An&nbsp;Outlook on&nbsp;Microplastic Environmental Impact Assessment, Challenges, and&nbsp;Opportunities Nikita&nbsp;Sharma1 &nbsp;· Suneetha&nbsp;Vuppu1 Received: 27 April 2023 / Accepted: 22 August 2023 © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023 Abstract Microplastics are tiny pieces of non-biodegradable plastic that can take thousands of years to break down. As microplastics degrade, they release harmful compounds into the environment, which can be found in the surroundings. The microplastics found in the environment are hard to detect and remove because of their small particle sizes. Microplastics cannot decompose naturally, so they accumulate in the environment and cause pollution. As a result, bioplastics can be produced from a vast array of substrates, including biopolymers, citrus peels, leather, and feather wastes. Blue-green microalgae namely Arthrospira platensis (spirulina) contains enzymes such as laccase and catalase which can be responsible for the degradation of bioplastics. In our study, we performed molecular docking to identify the binding afnities of diferent enzymes such as laccase and catalase with diferent substrates, focusing on determining the most suitable substrate for enhancing enzyme activity for degradation of bioplastics. The analysis revealed that veratryl alcohol is the most suitable substrate for laccase, whereas lignin is the more preferred substrate for catalase with the highest binding afnity score of −&nbsp;5.9 and −&nbsp;8.1&nbsp;kcal/mol. Moreover, degradation, challenges, opportunities, and applications of bioplastics in numerous domains such as cosmetics, electronics, agriculture, medical, textiles, and food industries have also been highlighted

In Silico Study of Enzymatic Degradation of Bioplastic by Microalgae: An Outlook on Microplastic Environmental Impact Assessment, Challenges, and Opportunities" Sharma N and Vuppu S

Journal: Environmental Monitoring and Assessment.

The utilization of natural eco-benign sources for sustainable management to preserve hides and docking analysis of identified potential phytochemicals.NIKITA AND SUNEETHA .

<h2>Recent Review on the Extraction and Qualitative Assay of Cysteine and Other Amino Acids from Vellore Feather Waste and Molecular Docking Studies of Cysteine for Pharmacological Applications</h2><ul><li><a href="https://link.springer.com/article/10.1007/s12033-023-00862-4#auth-Sathvika-Kamaraj-Aff1">Sathvika Kamaraj</a> &amp;</li><li><a href="https://link.springer.com/article/10.1007/s12033-023-00862-4#auth-Suneetha-Vuppu-Aff1">Suneetha Vuppu</a></li></ul><a href="https://link.springer.com/journal/12033">Molecular Biotechnology</a> (2023)

Recent Review on the Extraction and Qualitative Assay of Cysteine and Other Amino Acids from Vellore Feather Waste and Molecular Docking Studies of Cysteine for Pharmacological Applications

Abstract Recent studies confrm foral waste as one of the crucial and most neglected municipal solid waste (MSW) in India due to its traditional mode of disposal into rivers and surroundings, which eventually afects the environment and ultimately leads to health issues. Floral waste is considered as one of the crucial and most neglected municipal solid waste (MSW) in India due to its traditional mode of disposal into rivers and surroundings, which eventually afects the environment and ultimately lead to health issues. Our study aims to investigate the methanolic extracts of Ixora coccinea waste (Rubiaceae), Chrysanthemum morifolium waste (Asteraceae) and Floral waste (contains several foral debris) for characterisation for phytochemical screening by using GC–MS and FTIR, statistical optimisation (Lipinski’s Rule of Five), physicochemical (ADMET) and in-silico studies. Gas Chromatography–Mass Spectrometry analysis confrmed 26 volatile compounds. Fourier Transform Infra-Red Spectroscopy analysis provides characteristic functional groups. Subsequently, statistical optimisation analysis was performed using Lipinski’s analysis. Furthermore, ADMET analysis confrms the physicochemical properties of these bioactive compounds. In addition, using one-way ANOVA, which provides p≤0.05, indicates signifcance. Phytochemical studies confrm all phytochemicals in the foral waste except glycoside. In the quantitative estimation of phenols and favonoids, foral waste had the highest Total Phenolic Content, and Ixora coccinea waste had the highest Total Flavonoid Content with 19.07&nbsp;mg&nbsp;GAE/g and 10&nbsp;mg&nbsp;QE/g DE, respectively. The interactions of the three identifed phytocompounds of Floral waste were analysed for their medicinal properties using in-silico molecular docking studies. Results show that 12, oleanen-3-yl acetate (3-alpha), might have a maximum binding score followed by eicosane-7 hexyl and tetracosane. Finally, we focused on foral waste debris degradation by using the baiting technique. T

chemical papers

GC–MS, FTIR and physico-chemical analysis of phytochemicals from Vellore floral waste and its in-silico studies  <ul><li>Content type:Original Paper</li><li>Published: 24 August 2023</li></ul>